/*
 * Peptider Publications
 * Editorial / newspaper stylesheet. One narrow reading column on every viewport
 * (it never goes full-width on desktop), cream paper, ink type, hairline rules.
 * No client JS, no gradients, no shadows, no glass — calm and source-forward.
 *
 * Palette: white / cream / black / graphite / sandywhite.
 * Type: serif for prose + headlines, sans for micro-labels (kickers, meta, nav).
 */

:root {
  --page: #f6f1e7;          /* cream paper (page background) */
  --paper: #fffdf8;         /* lighter surface */
  --sand: #ece3d1;          /* sandywhite panel */
  --sand-soft: #f0e9da;
  --ink: #18140d;           /* near-black headline ink */
  --ink-soft: #2c2820;      /* body text */
  --graphite: #6a6253;      /* secondary text + labels */
  --graphite-soft: #8b8275; /* faint */
  --rule: #ddd3c0;          /* hairline rule */
  --rule-strong: #bcb19a;   /* stronger rule */
  /* Restrained semantic accents — used only on thin left rules where caution matters. */
  --warn: #8a6d39;
  --danger: #8a3a32;
  --evidence: #4c6b51;

  /* Institutional reading serif. */
  --serif: Georgia, "Times New Roman", "Liberation Serif", Charter, serif;
  /* Condensed grotesque for newspaper-style labels, kickers, datelines, headers. */
  --sans: "Arial Narrow", "Roboto Condensed", "Liberation Sans Narrow", ui-sans-serif, system-ui, sans-serif;
  --mono: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;

  /* Reading column: stays narrow even on wide screens. */
  --measure: 39rem;
  --pad: 1.3rem;

  --s1: 0.3rem;
  --s2: 0.55rem;
  --s3: 0.8rem;
  --s4: 1.2rem;
  --s5: 1.8rem;
  --s6: 2.6rem;
}

*,
*::before,
*::after {
  box-sizing: border-box;
}

html {
  border-top: 3px solid var(--ink); /* full-bleed nameplate rule */
  color: var(--ink-soft);
  background: var(--page);
  font-size: 17px;
  line-height: 1.48;
  text-rendering: optimizeLegibility;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  -webkit-text-size-adjust: 100%;
  text-size-adjust: 100%;
}

body {
  min-height: 100vh;
  margin: 0;
  font-family: var(--serif);
  font-kerning: normal;
  font-variant-numeric: oldstyle-nums proportional-nums;
}

::selection {
  background: rgba(24, 20, 13, 0.13);
}

img,
svg {
  max-width: 100%;
}

img {
  height: auto;
}

a {
  color: var(--ink);
  text-decoration: underline;
  text-decoration-color: var(--rule-strong);
  text-decoration-thickness: 1px;
  text-underline-offset: 0.16em;
}

a:hover {
  text-decoration-color: var(--ink);
}

a:focus-visible,
summary:focus-visible {
  outline: 2px solid var(--ink);
  outline-offset: 2px;
}

.visually-hidden {
  position: absolute;
  width: 1px;
  height: 1px;
  padding: 0;
  margin: -1px;
  overflow: hidden;
  clip: rect(0 0 0 0);
  white-space: nowrap;
  border: 0;
}

.skip-link {
  position: absolute;
  top: 0.5rem;
  left: var(--pad);
  z-index: 10;
  transform: translateY(-160%);
  padding: 0.5rem 0.85rem;
  background: var(--ink);
  color: var(--page);
  font-family: var(--sans);
  font-size: 0.8rem;
  text-decoration: none;
}

.skip-link:focus {
  transform: translateY(0);
}

/* ---- narrow column: header, breadcrumbs, main, footer all share it ---- */

.site-header,
.breadcrumbs,
main,
.site-footer {
  width: min(100% - (var(--pad) * 2), var(--measure));
  margin-inline: auto;
}

main {
  padding: var(--s5) 0 var(--s6);
}

/* ---- masthead ---- */

.site-header {
  display: flex;
  align-items: baseline;
  justify-content: space-between;
  gap: var(--s3);
  padding: var(--s3) 0 var(--s2);
  border-bottom: 1px solid var(--rule-strong);
}

.site-title {
  display: inline-flex;
  align-items: center;
  gap: 0.6rem;
  color: var(--ink);
  text-decoration: none;
}

.site-logo {
  width: 1.85rem;
  height: 2.15rem;
  object-fit: contain;
}

.site-title-label {
  font-family: var(--serif);
  font-size: 1.32rem;
  font-weight: 700;
  letter-spacing: 0.01em;
}

.site-nav {
  display: flex;
  gap: var(--s3);
  font-family: var(--sans);
  font-size: 0.72rem;
  font-weight: 600;
  letter-spacing: 0.09em;
  text-transform: uppercase;
}

.site-nav a {
  color: var(--graphite);
  text-decoration: none;
}

.site-nav a:hover {
  color: var(--ink);
}

/* ---- breadcrumbs ---- */

.breadcrumbs {
  padding-top: var(--s3);
  font-family: var(--sans);
  font-size: 0.7rem;
  letter-spacing: 0.07em;
  text-transform: uppercase;
  color: var(--graphite);
}

.breadcrumbs ol {
  display: flex;
  flex-wrap: wrap;
  gap: 0.4rem;
  margin: 0;
  padding: 0;
  list-style: none;
}

.breadcrumbs li + li::before {
  margin-right: 0.4rem;
  color: var(--rule-strong);
  content: "/";
}

.breadcrumbs a {
  color: inherit;
  text-decoration: none;
}

.breadcrumbs a:hover {
  color: var(--ink);
}

.breadcrumbs li[aria-current="page"] {
  color: var(--ink);
}

/* ---- footer ---- */

.site-footer {
  margin-top: var(--s6);
  padding: var(--s4) 0 var(--s5);
  border-top: 1px solid var(--rule);
  font-family: var(--sans);
  font-size: 0.74rem;
  color: var(--graphite);
}

.site-footer p {
  margin: 0 0 0.3rem;
}

/* ---- headings & prose ---- */

h1,
h2,
h3,
h4 {
  margin: 0;
  color: var(--ink);
  font-family: var(--serif);
  line-height: 1.06;
}

h1 {
  font-size: 2.4rem;
  font-weight: 700;
  letter-spacing: -0.02em;
}

h2 {
  font-size: 1.5rem;
  font-weight: 700;
}

h3 {
  font-size: 1.18rem;
  font-weight: 700;
}

h4 {
  font-size: 1.02rem;
  font-weight: 700;
}

p,
ul,
ol,
dl,
blockquote,
table,
figure {
  margin: var(--s3) 0 0;
}

:where(p, ul, ol):first-child {
  margin-top: 0;
}

.lede {
  color: var(--ink-soft);
  font-size: 1.12rem;
  line-height: 1.38;
}

.eyebrow,
.kicker,
.summary-label {
  display: block;
  font-family: var(--sans);
  font-size: 0.7rem;
  font-weight: 700;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--graphite);
}

.publication-meta,
.article-meta,
.source-meta,
.reading-time,
.compound-aka,
.muted,
.empty,
.ref-desc,
.article-desc {
  font-family: var(--sans);
  font-size: 0.79rem;
  line-height: 1.4;
  color: var(--graphite);
}

/* ---- home ---- */

.publications-home-hero {
  margin-bottom: var(--s5);
  padding: var(--s4) 0;
  border-bottom: 1px solid var(--rule-strong);
}

.publications-home-hero .lede {
  margin: 0;
  max-width: 32rem;
}

.ref-index {
  margin-bottom: var(--s6);
}

.ref-index h2,
.article-index h2 {
  margin: 0 0 var(--s2);
  padding-bottom: var(--s2);
  border-bottom: 1px solid var(--rule-strong);
  font-family: var(--sans);
  font-size: 0.78rem;
  font-weight: 700;
  letter-spacing: 0.09em;
  text-transform: uppercase;
  color: var(--graphite);
}

.ref-list,
.article-list {
  margin: 0;
  padding: 0;
  list-style: none;
}

.ref-item,
.article-item {
  padding: var(--s3) 0;
  border-bottom: 1px solid var(--rule);
}

.ref-link,
.article-link {
  font-family: var(--serif);
  font-size: 1.1rem;
  font-weight: 700;
  line-height: 1.2;
  color: var(--ink);
  text-decoration: none;
}

.ref-link:hover,
.article-link:hover {
  text-decoration: underline;
}

.ref-desc,
.article-desc {
  margin: 0.3rem 0 0;
}

.article-meta {
  margin: 0.25rem 0 0;
}

/* ---- publication / reference page ---- */

.publication {
  max-width: 100%;
}

.publication-header,
.page-header {
  margin-bottom: var(--s4);
  padding-bottom: var(--s3);
  border-bottom: 1px solid var(--rule-strong);
}

.publication-header h1,
.page-header h1 {
  margin-top: var(--s2);
  font-size: 2rem;
}

.publication-header .lede {
  margin-top: var(--s3);
}

.publication-header .publication-meta,
.page-header .publication-meta {
  margin-top: var(--s3);
}

.compound-aka {
  margin-top: var(--s1);
  font-style: italic;
}

.compound-status-note {
  margin-top: var(--s3);
  padding: var(--s2) var(--s3);
  border-left: 2px solid var(--rule-strong);
  background: var(--sand-soft);
  font-family: var(--sans);
  font-size: 0.79rem;
  line-height: 1.4;
  color: var(--graphite);
}

/* compound spec table */
.spec {
  margin-top: var(--s4);
  border-top: 1px solid var(--rule-strong);
  font-family: var(--sans);
}

.spec-row {
  display: grid;
  grid-template-columns: 8.5rem minmax(0, 1fr);
  gap: var(--s1) var(--s3);
  padding: 0.55rem 0;
  border-bottom: 1px solid var(--rule);
}

.spec-row dt {
  margin: 0;
  font-size: 0.7rem;
  font-weight: 700;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--graphite);
}

.spec-row dd {
  margin: 0;
  font-size: 0.92rem;
  color: var(--ink-soft);
}

.spec-mono {
  font-family: var(--mono);
  font-size: 0.82rem;
  overflow-wrap: anywhere;
}

/* ---- body prose ---- */

.publication-body {
  margin-top: var(--s4);
  font-size: 1rem;
  line-height: 1.54;
}

.publication-body > * + * {
  margin-top: var(--s3);
}

.publication-body h2 {
  margin-top: var(--s5);
  padding-top: var(--s3);
  border-top: 1px solid var(--rule);
  font-size: 1.28rem;
  scroll-margin-top: 1rem;
}

.publication-body h3 {
  margin-top: var(--s4);
  font-size: 1.08rem;
  scroll-margin-top: 1rem;
}

.publication-body ul,
.publication-body ol {
  padding-left: 1.3rem;
}

.publication-body li + li {
  margin-top: 0.3rem;
}

.publication-body blockquote {
  margin-left: 0;
  padding-left: var(--s3);
  border-left: 2px solid var(--rule-strong);
  color: var(--graphite);
  font-style: italic;
}

.publication-body table {
  display: block;
  width: 100%;
  overflow-x: auto;
  border-top: 2px solid var(--ink);
  border-bottom: 2px solid var(--ink);
  border-collapse: collapse;
  font-family: var(--sans);
  font-size: 0.85rem;
}

.publication-body th,
.publication-body td {
  padding: 0.55rem 0.7rem;
  border-bottom: 1px solid var(--rule);
  text-align: left;
  vertical-align: top;
}

.publication-body th {
  font-size: 0.7rem;
  font-weight: 700;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: var(--ink);
}

.publication-body code {
  padding: 0.05rem 0.3rem;
  border-radius: 2px;
  background: var(--sand);
  font-family: var(--mono);
  font-size: 0.86em;
}

.publication-body pre {
  overflow-x: auto;
  padding: var(--s3);
  border-radius: 3px;
  background: var(--ink);
  color: var(--page);
}

.publication-body pre code {
  padding: 0;
  background: none;
  color: inherit;
}

/* ---- table of contents ---- */

.toc {
  margin-top: var(--s4);
  padding: var(--s3) 0;
  border-top: 1px solid var(--rule);
  border-bottom: 1px solid var(--rule);
  font-family: var(--sans);
}

.toc-title {
  margin: 0 0 var(--s2);
  font-size: 0.72rem;
  font-weight: 700;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--graphite);
}

.toc ul {
  display: grid;
  gap: 0.3rem;
  margin: 0;
  padding: 0;
  list-style: none;
  font-size: 0.86rem;
}

.toc a {
  color: var(--ink-soft);
  text-decoration: none;
}

.toc a:hover {
  color: var(--ink);
  text-decoration: underline;
}

.toc-l3 {
  padding-left: var(--s3);
}

/* ---- key takeaways / hero summary ---- */

.hero-summary-panel {
  margin-top: var(--s4);
  padding-top: var(--s3);
  border-top: 1px solid var(--rule);
}

.hero-summary {
  margin: var(--s2) 0 0;
  padding: 0;
  list-style: none;
  display: grid;
  gap: 0.5rem;
}

.hero-summary li {
  position: relative;
  padding-left: 1.1rem;
}

.hero-summary li::before {
  position: absolute;
  left: 0;
  color: var(--graphite);
  content: "\2014"; /* em dash */
}

.key-takeaways {
  margin-top: var(--s4);
  padding: var(--s3) 0;
  border-top: 1px solid var(--rule-strong);
  border-bottom: 1px solid var(--rule);
}

.key-takeaways h2 {
  margin: 0 0 var(--s2);
  font-family: var(--sans);
  font-size: 0.78rem;
  font-weight: 700;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--graphite);
}

.key-takeaways ul {
  margin: 0;
  padding-left: 1.1rem;
}

/* ---- callouts ---- */

.callout {
  margin-top: var(--s4);
  padding: var(--s2) var(--s3);
  border-left: 3px solid var(--graphite);
  background: var(--sand-soft);
}

.callout-title {
  margin: 0 0 0.25rem;
  font-family: var(--sans);
  font-size: 0.76rem;
  font-weight: 700;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--ink);
}

.callout p {
  margin: 0;
}

.callout p + p {
  margin-top: 0.5rem;
}

.callout-warning {
  border-left-color: var(--warn);
}

.callout-limitation {
  border-left-color: var(--danger);
}

.callout-regulatory {
  border-left-color: var(--ink);
}

.callout-evidence {
  border-left-color: var(--evidence);
}

/* ---- figures (zero-dependency SVG engine output) ---- */

.pt-figure {
  margin: var(--s5) 0;
  padding: var(--s3) 0;
  border-top: 1px solid var(--rule-strong);
  border-bottom: 1px solid var(--rule);
}

.pt-figure svg {
  display: block;
  width: 100%;
  height: auto;
}

.pt-figure figcaption {
  margin-top: var(--s2);
  font-family: var(--sans);
  font-size: 0.76rem;
  line-height: 1.5;
  color: var(--graphite);
}

/* ---- sources: cards, groups, inline cites ---- */

.source-cards {
  display: grid;
  gap: var(--s3);
  margin-top: var(--s3);
}

.source-card {
  padding: 0;
}

.source-title {
  margin: 0;
  font-family: var(--serif);
  font-size: 1.02rem;
  font-weight: 700;
  line-height: 1.3;
}

.source-title cite {
  font-style: normal;
}

.source-title a {
  text-decoration: none;
}

.source-title a:hover {
  text-decoration: underline;
}

.source-meta {
  display: flex;
  flex-wrap: wrap;
  gap: 0.3rem 0.6rem;
  align-items: baseline;
  margin-top: 0.35rem;
}

.source-type {
  font-family: var(--sans);
  font-size: 0.66rem;
  font-weight: 700;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--graphite);
}

.source-desc {
  margin-top: 0.4rem;
  font-size: 0.96rem;
  color: var(--ink-soft);
}

.source-url,
.source-permalink {
  margin-top: 0.3rem;
  font-family: var(--sans);
  font-size: 0.76rem;
  overflow-wrap: anywhere;
}

.source-inline {
  font-style: italic;
}

.source-group {
  margin-top: var(--s3);
}

.source-group-title {
  margin: 0 0 var(--s2);
  font-family: var(--sans);
  font-size: 0.74rem;
  font-weight: 700;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--graphite);
}

.source-group-type + .source-group-type {
  margin-top: var(--s3);
  padding-top: var(--s3);
  border-top: 1px solid var(--rule);
}

.source-group-label {
  margin: var(--s2) 0 var(--s1);
  font-family: var(--sans);
  font-size: 0.68rem;
  font-weight: 700;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--graphite);
}

/* ---- compound card component ---- */

.compound-card {
  margin-top: var(--s4);
  padding: var(--s3) 0;
  border-top: 1px solid var(--rule-strong);
  border-bottom: 1px solid var(--rule);
}

.compound-card h4 {
  margin: 0;
  font-family: var(--serif);
  font-size: 1.1rem;
}

.compound-card p {
  margin-top: 0.3rem;
  color: var(--ink-soft);
}

.compound-status {
  font-family: var(--sans);
  font-size: 0.74rem;
  color: var(--graphite);
}

/* ---- stat ---- */

.stat {
  margin-top: var(--s4);
  padding: var(--s3) 0;
  border-top: 1px solid var(--rule-strong);
  border-bottom: 1px solid var(--rule);
}

.stat-value {
  margin: 0;
  font-family: var(--serif);
  font-size: 2rem;
  font-weight: 800;
  line-height: 1;
  color: var(--ink);
}

.stat-label {
  margin-top: 0.35rem;
  font-family: var(--sans);
  font-size: 0.76rem;
  font-weight: 700;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--graphite);
}

.stat-caption {
  margin-top: 0.2rem;
  font-family: var(--sans);
  font-size: 0.8rem;
  color: var(--graphite);
}

/* ---- timeline ---- */

.timeline {
  margin-top: var(--s4);
  padding: 0;
  list-style: none;
  border-top: 1px solid var(--rule-strong);
}

.timeline-item {
  display: grid;
  grid-template-columns: 6rem minmax(0, 1fr);
  gap: var(--s1) var(--s3);
  padding: var(--s2) 0;
  border-bottom: 1px solid var(--rule);
}

.timeline-item time {
  font-family: var(--sans);
  font-size: 0.76rem;
  color: var(--graphite);
}

.timeline-title {
  font-weight: 600;
}

.timeline-source {
  font-family: var(--sans);
  font-size: 0.74rem;
}

/* ---- faq ---- */

.faq {
  margin-top: var(--s4);
}

.faq-item {
  padding: var(--s3) 0;
  border-top: 1px solid var(--rule);
}

.faq-q {
  margin: 0;
  font-weight: 700;
  color: var(--ink);
}

.faq-a {
  margin-top: 0.3rem;
  color: var(--ink-soft);
}

/* ---- end-of-article sections: section labels with a rule ---- */

.evidence-summary,
.references,
.related-articles,
.related-compounds,
.coverage {
  margin-top: var(--s5);
}

.evidence-summary h2,
.references h2,
.related-articles h2,
.related-compounds h2,
.coverage h2 {
  margin: 0 0 var(--s3);
  padding-top: var(--s3);
  border-top: 1px solid var(--rule-strong);
  font-family: var(--sans);
  font-size: 0.78rem;
  font-weight: 700;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--graphite);
}

.evidence-group {
  margin-top: var(--s3);
}

.evidence-group h3 {
  margin: 0 0 var(--s2);
  font-family: var(--sans);
  font-size: 0.74rem;
  font-weight: 700;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--graphite);
}

/* numbered references */
.reference-list {
  margin: 0;
  padding: 0;
  list-style: none;
  counter-reset: ref;
}

.reference-list > li {
  display: grid;
  grid-template-columns: 1.4rem minmax(0, 1fr);
  gap: 0.5rem;
  padding: 0.55rem 0;
  border-top: 1px solid var(--rule);
  counter-increment: ref;
}

.reference-list > li:first-child {
  border-top: 0;
  padding-top: 0;
}

.reference-list > li::before {
  font-family: var(--sans);
  font-size: 0.74rem;
  font-weight: 700;
  line-height: 1.5;
  color: var(--graphite);
  content: counter(ref) ".";
}

/* references are compact native <details> disclosures (no JS) */
.source-item > summary {
  position: relative;
  padding-right: 1.4rem;
  list-style: none;
  cursor: pointer;
}

.source-item > summary::-webkit-details-marker {
  display: none;
}

.source-item > summary::after {
  position: absolute;
  top: 0.32rem;
  right: 0.15rem;
  width: 0.4rem;
  height: 0.4rem;
  border-right: 1.5px solid var(--graphite);
  border-bottom: 1.5px solid var(--graphite);
  transform: rotate(45deg);
  content: "";
}

.source-item[open] > summary::after {
  top: 0.42rem;
  transform: rotate(225deg);
}

.source-item > summary:hover::after {
  border-color: var(--ink);
}

.source-item .source-title {
  display: block;
  font-style: normal;
  font-size: 0.94rem;
  line-height: 1.25;
}

.source-item > summary .source-meta {
  margin-top: 0.18rem;
  font-size: 0.72rem;
}

.source-item .source-desc {
  margin-top: 0.5rem;
  font-size: 0.95rem;
}

/* related compounds: inline link list */
.compound-links {
  display: flex;
  flex-wrap: wrap;
  gap: 0.4rem 1rem;
  margin: 0;
  padding: 0;
  list-style: none;
  font-family: var(--sans);
  font-size: 0.88rem;
}

.compound-links a {
  color: var(--ink);
}

.compound-links li span {
  color: var(--graphite);
}

/* ---- empty / 404 ---- */

.empty {
  padding: var(--s4) 0;
}

.notfound {
  padding: var(--s5) 0 var(--s6);
}

.notfound .kicker {
  margin-bottom: var(--s2);
}

/* ---- responsive: narrow-first; only collapse the few 2-col grids ---- */

@media (max-width: 30rem) {
  html {
    font-size: 16.5px;
  }

  h1 {
    font-size: 2rem;
  }

  .publication-header h1,
  .page-header h1 {
    font-size: 1.8rem;
  }

  .lede {
    font-size: 1.08rem;
  }

  .spec-row,
  .timeline-item {
    grid-template-columns: 1fr;
    gap: 0.15rem;
  }
}

/* ---- print: clean, ink-on-white, drop chrome ---- */

@media print {
  html {
    border-top: 0;
  }

  body {
    background: #fff;
    color: #000;
  }

  .site-nav,
  .breadcrumbs,
  .toc,
  .skip-link {
    display: none;
  }

  a {
    color: #000;
    text-decoration: none;
  }

  .pt-figure,
  .source-card,
  .callout,
  .reference-list > li {
    break-inside: avoid;
  }
}